Type 2 DM in adult particularly in overwt patients when dietary management & exercise alone does not result in adequate glycaemic control. May be used as monotherapy or in combination w/ other oral antidiabetic agents or insulin.
Monotherapy & combination w/ other oral antidiabetic agents500-mg tab Initially 1 tab once daily. Increase dose by increments of 500 mg every 10-15 days. Max: 2,000 mg (4 tab) once daily. 750-mg tab 1 tab once daily. Max: 2 tab once daily. Adjust all doses based on blood glucose measurements after 10-15 days. Patient already treated w/ metformin Start w/ same daily dose of metformin IR tab. Transfer from another oral antidiabetic agents: Discontinue the other agent & initiate at dose indicated previously. Combination w/ insulin Initially 500 mg once daily, adjust dose of insulin based on blood glucose measurements.
Lactic acidosis may occur in patients w/ significant renal failure. Monitor renal function regularly. Discontinue use prior to or during iodinated contrast agent administration; 48 hr before elective surgery or if metabolic acidosis is suspected. Increased risk of hypoglycaemia w/ concomitant use of insulin or other oral antidiabetics. Pregnancy. Childn. Elderly.
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